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RAD-140 is one of the more potent SARMs and it is suppressive. It is critical that you are familiar and prepared with your PCT protocol before you start your cycle to avoid unwanted side-effects, can mk677 cause anxiety. YK-11 vs RAD 140. Andarine, along with Ostarine, is the safest choice for females (at a VERY low dose) who have decided to take the SARM route and want to minimise the risk of developing side effects, can mk677 cause anxiety.